The complete skin secretome: From stem cell science to regenerative breakthrough

Your skin holds the key to its own renewal. Every cell speaks a language perfected over millions of years—a dialogue of revitalization and regeneration.

But as time passes, this communication weakens. To restore youthful skin, you need more than fragments of the conversation. You need the whole story. That’s what PROVOQUE™ delivers.

Abundant in the skin stem cell secretome along with growth factors and exosomes, fetuin-A is the keychain that holds the keys to anti-aging benefits. Learn how fetuin-A transports growth factors and exosomes across the skin barrier, amplifying their regenerative power.

Skin cells no longer have to act their age

Before

After 12 weeks

Clinical study results: Histological analysis

  • Restored skin surface
  • Improved skin texture
  • More radiant appearance
  • 25% more collagen
  • Improved skin barrier

H&E stain of full-thickness skin biopsy, BID topical application of PROVOQUE Facial Serum ​

Overall skin rejuvenation for provocative results

Percentage Improvement in Key Skin Metrics: Dermatologist’s Assessment

Legend

  • Deep Wrinkles
  • Tone
  • Clarity
  • Redness
  • Roughness, softness
  • Fine Line Wrinkles
  • Radiance

*P < 0.05

Nistor G, Poole AJ, Draelos Z, et al. Human Stem Cell-Derived Skin Progenitors Produce Alpha 2-HS Glycoprotein (Fetuin): A Revolutionary Cosmetic Ingredient. J Drugs Dermatology. 2016;15(5):583-598

Coming soon in the PROVOQUE pipeline

The same breakthrough science behind PROVOQUE facial serum is paving the way for future innovations. By harnessing the full potential of the secretome, our pipeline includes a sterile post-procedure serum and a hair restoration treatment. Stay tuned as we push the boundaries of regenerative aesthetics.

Let’s redefine the future of aesthetics

Ready to unlock the power of regenerative skincare? Connect with us to learn more about the breakthrough science behind PROVOQUE.

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